Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population.
نویسندگان
چکیده
Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder.
منابع مشابه
Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.
The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implicatio...
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متن کاملStudies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16.
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To define the PKD1 locus further, the gene involved in the most frequent form of adult polycystic kidney disease, probes from 16 polymorphic loci were mapped on 16p13.1-pter with the combined use of cell lines containing rearranged chromosomes and family studies. Five breakpoints in the distal part of 16p arbitrarily subdivided the loci into five groups. By analysing 58 recombination events amo...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 24 8 شماره
صفحات -
تاریخ انتشار 1987